Home > Envelope Density Analyzer – the GeoPyc 1360

Envelope Density Analyzer – the GeoPyc 1360

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article image GeoPyc 1360 envelope density analyser

Particle & Surface Sciences  have introduced the Micromeritics’ GeoPyc 1360 Envelope density analyser, an analytical tool for pharmaceutical roller compaction applications.

Micromeritics’ GeoPyc 1360 envelope density analyser is suitable for the determination of the bulk density of roller compactions and the ribbon created during the process.

Roller compactors have become commonplace in the production of solid dosage pharmaceuticals.

Low API content formulations can be problematic if appropriate steps are not taken to ensure adequate and consistent drug loading in each finished solid dosage form. Adding a roller compaction step to the process ensures content uniformity.

Small particle size of APIs, for example, nanoparticles, can be difficult to move and uniformly disperse in a powder or granulation bed. Movement of these materials becomes predictable and consistent when the roller compaction step is incorporated into the process.

When adding a roller compactor, specific analytical tests to monitor the performance of the device and to quantify and qualify the effects of subtle changes to the compactor’s settings should be considered.

The density profile of the material produced during the compaction step should be monitored during the formulation, process development and production phases.

The GeoPyc 1360 envelope density analyser is based on the Archimedes principal and utilises a quasi-fluid displacement medium composed of non hazardous microspheres having a high degree of flowability. This approach eliminates the need for oils, solvents, and mercury that are traditionally required as a displacement medium.

Micromeritics’ patented DryFlo displacement material does not wet the sample or fill its external or internal pores. A light shaking or dusting removes the DryFlo after analysis. Therefore, the roller compaction ribbon can be reused or retested.

The GeoPyc 1360 envelope density analyser collects the displacement data, performs the calculations, and displays or prints the results.

A variety of sample chambers is available to accommodate a range of sample sizes. The GeoPyc 1360 envelope density analyser features density technology (Micromeritics’ AccuPyc II 1340 Gas Displacement Pycnometer) and calculates the bulk or envelope density of the ribbon, percent porosity and total pore volume.

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