A new Mettler Toledo
white paper explores the interrelationship of two critical chemistry methodologies, flow chemistry and mid-infrared spectroscopy in today's highly competitive R&D environment.
Novel chemistry methodologies that enable a wide range of reactions in product development are driven by a need to improve quality, yield and cycle time coupled with a desire for high personal performance.
The new Mettler Toledo white paper titled ‘Enhanced Development and Control of Continuous Processes: A Review of Modern Technologies’ joins the company's extensive collection of thought-leadership resources.
In terms of flow chemistry's revolutionary role in pharmaceutical and fine chemistry environments, the paper explores its ability to enhance product quality, increase yield, elucidate synthetic route and improve reaction safety while reducing cycle time, which is critical to reducing development costs and capturing market share in today's competitive manufacturing arena.
The paper explores mid-infrared (IR) spectroscopy as a convenient and non-destructive method for real-time inline flow chemistry monitoring, because it allows real-time data gathering on the formation of products and reactive intermediates. This instantaneous feedback on how changing a parameter such as flow rate or reaction temperature affects a reaction enables faster, safer and more cost-effective process optimisation.
The intensity of IR energy absorbed at a particular wavelength is defined by Beer's law to be proportional to concentration, making it possible to track the relative concentration of individual reaction components using mid-IR-enabled technology.
Employing this type of technology not only results in improved reaction understanding, it also allows researchers to overcome what used to be significant optimisation issues, such as making a controlled addition of reagent stoichiometries to a product stream using output data from a prior reaction stage when performing multi-step synthesis.
The paper describes specific instances where mid-IR technology and flow chemistry principles were applied to monitor product streams/ dispersion effects in continuous flow reactors and allowed successful third-stream reagent addition, helping to eliminate poor reaction control and waste production.